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Overview: 

Sickle cell anaemia and thalassaemia are debilitating blood diseases that arise due to mutations in adult globin genes. In this project, we will investigate the signaling cascades and networks involved in developmental regulation of globin gene expression, with an ultimate aim of reactivating the foetal globin genes. 

Overview: 

Obesity is currently one of the Western world’s greatest medical challenges. In this project, we will investigate the transcriptional control of adipogenesis by identifying the signaling cascades and downstream target genes controlling fat cell development. In this project, we will investigate the transcriptional control of adipogenesis by identifying the signaling cascades and downstream target genes controlling fat cell development. 

Overview: 

The ability to artificially regulate gene expression offers immense promise for the treatment of human diseases. In this project, we will apply knowledge of how natural transcription factors regulate their target genes to engineer a new generation of more potent artificial factors. In this project, we will apply knowledge of how natural transcription factors regulate their target genes to engineer a new generation of more potent artificial factors.