We are offering a prestigious Scientia PhD Scholarship for 2018. Please see this link for more information http://www.2025.unsw.edu.au/apply/scientia-phd-scholarships/using-immune-cells-combat-obesity. Please don't hesitate to contact Kate Quinlan (firstname.lastname@example.org) if you would like more information.
Using Immune Cells to Combat Obesity
Obesity is a global problem. We study the molecular pathways that control the switch between fat accumulation and fat burning. Researchers have recently discovered that humans have cells called "beige adipocytes" that specialise in burning fat. Our team has recently identified signals from immune cells that convert normal adipocytes into "beige adipocytes". We hypothesise that these signals can be used in a therapeutic setting to create more "beige adipocytes" to promote fat loss. This project will combine cell biology, genetics, molecular biology and immunology approaches. It will utilise transgenic animal models, cell culture models and state-of-the-art in vitro techniques including CRISPR/Cas9 genome editing. Ultimately we hope to determine how normal adipocytes are converted into "beige adipocytes" and translate these findings into a therapeutic strategy to reverse obesity.